Jeremy M. Boss, PhD
We examine the mechanisms that regulate the major histocompatibility complex class-II gene system, which is responsible for the presentation of antigens to the immune system. We also study the regulation of the programmed death-1 (PD-1) gene. PD-1 functions to dampen and restrict immune responses during persistent infections, such as those associated with HIV. By understanding the mechanisms that govern regulation of these genes, reagents may ultimately be designed to help improve vaccination and combat chronic conditions.