Max D. Cooper, MD
My laboratory pursues ontogenetic and phylogenetic studies of the adaptive immune system in parallel with the analysis of immunological diseases in humans. Current projects include the role of immunoglobulin and non-immunoglobulin genes in normal and abnormal B cell development, and the evolution of alternative adaptive immune systems in vertebrates.
I study hemopoietic stem cell differentiation along lymphoid and myeloid pathways. This information on normal development of cells belonging to the immune system is used for analysis and treatment of individuals with immunodeficiencies and with malignancies of the immune system. Many of the activities in this laboratory are devoted to the study of the life history of B and T cells, and how their development may go awry. Current research focuses on the role of immunoglobulin and non-immunoglobulin genes in B cell development, and evolution of the adaptive immune system.