J. Brandon Dixon, PhD

Biography

J. Brandon Dixon, Ph.D.

Email: brandon.dixon@me.gatech.edu

Assistant Professor

George W. Woodruff School of Mechanical Engineering

Dr. Dixon’s research focuses on elucidating and quantifying the molecular aspects that control lymphatic function. Through the use of tissue-engineered model systems and animal models, our research group is shedding light on the active roles of the lymphatic system in lipid metabolism and transport.

We seek to understand the underlying mechanisms involved in regulating lymphatic function and their failures in lymphatic disease. To do this we develop tissue engineering strategies to recreate in vivo lymphatic physiology on a chip for molecular studies and imaging approaches to quantify lymphatic function in vivo. The lymphatic vasculature is a major component of the mammalian immune system. Given the integral role the lymphatic circulation plays in transporting particulate and cells from the interstitium to the lymph nodes, we have projects involving the role of lymphatic transport in immune responses to skin vaccination, the role of lymphatics in exosome transport from peripheral immune cells, cancer cells, and parasites to the down stream lymph node. We are also interested in the consequence of lymphatic dysfunction in the impaired resolution of inflammation that occurs in a variety of diseases.

Our research focuses on elucidating and quantifying the molecular aspects that control lymphatic function. Through the use of tissue-engineered model systems and animal models, our research is shedding light on the active roles of the lymphatic system in lipid metabolism and transport.