Dean P. Jones, PhD
Dean P Jones, Ph.D.
Dean P. Jones, Ph.D. is a Professor in the Department of Medicine (Pulmonary Division) at Emory University, Atlanta, GA. He received a Ph.D in Biochemistry from Oregon Health Sciences Univ., Portland, in 1976. He studied nutritional biochemistry at Cornell University and molecular toxicology at the Karolinska Institute as a post-doctoral fellow. He joined Emory University as an Asst Professor of Biochemistry in 1979, was subsequently promoted to Assoc. Prof in 1985 and Prof. of Biochemistry in 1990. He became Prof of Medicine in 2003. His central research focus is on redox mechanisms of oxidative stress. He currently directs the Emory Clinical Biomarkers Laboratory, which is focused on oxidative stress biomarkers and applications of 1H-NMR spectroscopy and Fourier-transform mass spectrometry for high-throughput clinical metabolomic analyses of nutritional and environmental factors in human health and disease.
The central research theme is to define redox control and signaling mechanisms and identify sites of disruption during oxidative stress. One aspect is focused on quantitative methods to measure redox state in subcellular compartments. This research has yielded new understanding of mitochondrial and nuclear redox during oxidative stress (Annu Rev Pharmacol Toxicol 2006, 46:215-234). These studies have led to the concept that oxidative stress can be measured clinically in terms of redox state of glutathione and cysteine pools in plasma, a concept that has been validated and is actively being pursued in a number of clinical studies (Antiox Redox Signal 2006, in press). With the recognition that oxidative stress represents disruption of redox signaling and control pathways, a major new initiative has been to develop metabolomics and clinical proteomics to study metabolic consequences of oxidation of thiol/disulfide redox state associated with aging, environmental toxicity and chronic disease. This research uses Fourier-transform mass spectrometry and nuclear magnetic resonance spectroscopy along with bioinformatics to determine how oxidative stress linked to dietary and environmental exposures impacts pathophysiologic measures of health and health risk.