Melissa Kemp, PhD

Biography

Melissa  Kemp, PhD

Associate Professor
Georgia Institute of Technology & Emory University  

The Kemp Lab laboratory investigates protein thiol oxidation and reduction as mechanisms of controlling signaling in immune cells. The challenges in quantifying protein oxidation and reactive oxygen species demand computational modeling-based approaches for gaining insight in the role of redox regulation in imunological signaling. We primarily focus on dynamic modeling of biochemical networks associated with cytokine and antigen receptors in T cells. We investigate how shifts in redox potential (e.g. via viral infection, aging, immortalization or differentiation) can alter the interpretation of receptor cues through thiol-based signaling mechanisms. Computational work is complimented by development of high-throughput experimental methods to address current limitations of data acquisition.